MOTS-c
A 16-amino-acid mitochondrial-derived peptide that regulates metabolism and insulin sensitivity.
What is MOTS-c?
A 16-amino-acid mitochondrial-derived peptide that regulates metabolism and insulin sensitivity. Encoded in mitochondrial DNA (12S rRNA), not nuclear genes. MOTS-c acts as a retrograde signal from mitochondria to the cell, often discussed alongside AMPK activation and “exercise mimetic” rodent studies. Trending in longevity and metabolic research; not a cosmetic INCI ingredient or an FDA-approved drug.
Where you will see MOTS-c
On product labels, look for the INCI name in the full ingredient list—not just front-of-pack nicknames. Concentration, formula pH, and what else is in the bottle all change how a peptide behaves on skin or hair.
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Common questions
What does MOTS-c mean?
A 16-amino-acid mitochondrial-derived peptide that regulates metabolism and insulin sensitivity. Encoded in mitochondrial DNA (12S rRNA), not nuclear genes. MOTS-c acts as a retrograde signal from mitochondria to the cell, often discussed alongside AMPK activation and “exercise mimetic” rodent studies. Trending in longevity and metabolic research; not a cosmetic INCI ingredient or an FDA-approved drug.
Is MOTS-c an INCI ingredient name?
Sometimes. Brands use nicknames on the front label and INCI names on the back. Search our directory with either form to find the matching peptide page.