Exenatide vs Semaglutide
Both are categorized under GLP-1 agonist in our directory—here is how they differ in name, use, and label context.
Exenatide
GLP-1 agonist
The first approved GLP-1 mimetic—derived from Gila monster saliva peptide exendin-4.
Exenatide was isolated from the Gila monster and modified for human use. It lowers blood glucose and modestly reduces weight. Largely replaced by newer GLP-1 drugs but remains a reference point for the peptide drug class…
Semaglutide
GLP-1 agonist
A GLP-1 receptor agonist peptide drug approved for type 2 diabetes and chronic weight management.
Semaglutide mimics glucagon-like peptide-1, slowing gastric emptying and increasing satiety. Weekly injection versions (Ozempic, Wegovy) produce significant weight loss in trials. It is a prescription drug—not a supple…
Quick comparison
- Exenatide: GLP-1 agonist — The first approved GLP-1 mimetic—derived from Gila monster saliva peptide exendin-4.…
- Semaglutide: GLP-1 agonist — A GLP-1 receptor agonist peptide drug approved for type 2 diabetes and chronic weight management.…